ULB Center for Diabetes Research


ULB Center for Diabetes Research


These are our publications in the last years



  1. Tsukamoto K, Cnop M, Mori D, Kume S, Anazawa T, Doi M, Chikazawa K, Matsumaru N. Future Perspectives for the Treatment of Diabetes: Importance of a Regulatory Framework. Ther Innov Regul Sci (online)

  2. Gotthardt M, Eizirik DL, Aanstoot HJ, Korsgren O, Mul D, Martin F, Boss M, Jansen TJP, van Lith SAM, Buitinga M, Eriksson O, Cnop M, Brom M. Diabetologia 61:2516-2519, 2018

  3. Colli ML, Hill JLE, Marroquí L, Chaffey J, Dos Santos RS, Leete P, Coomans de Brachène A, Paula FMM, Op de Beeck A, Castela A, Marselli L, Krogvold L, Dahl-Jorgensen K, Marchetti P, Morgan NG, Richardson SJ, Eizirik DL. PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction. EBioMedicine 36:367-375, 2018

  4. Eizirik DL, Gurzov EN. Can GABA turn pancreatic α-cells into β-cells? Nat Rev Endocrinol 14:629-630, 2018 

  5. Cosentino C, Toivonen S, Diaz Villamil E, Atta M, Ravanat JL, Demine S, Schiavo AA, Pachera N, Deglasse JP, Jonas JC, Balboa D, Otonkoski T, Pearson ER, Marchetti P, Eizirik DL, Cnop M, Igoillo-Esteve M. Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes. Nucleic Acids Res 46:10302-10318, 2018

  6. Alvelos MI, Juan-Mateu J, Colli ML, Turatsinze JV, Eizirik DL. Diabetes Obes Metab 20 Suppl 2:77-87, 2018

  7. Demine S, Balhuizen A, Debaille V, Joosten L, Fereau M, Chilla SNM, Millard I, Scharfmann R, Egrise D, Goldman S, Marchetti P, Gotthardt M, Laurent S, Burtea C, Eizirik DL. Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa. Molecules 23(9), 2018

  8. Cereijo R, Gavaldà-Navarro A, Cairó M, Quesada-López T, Villarroya J, Morón-Ros S, Sánchez-Infantes D, Peyrou M, Iglesias R, Mampel T, Turatsinze JV, Eizirik DL, Giralt M, Villarroya F. CXCL14, a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation. Cell Metabolism 28:750-763, 2018

  9. Sims EK, Evans-Molina C, Tersey SA, Eizirik DL, Mirmira RG. Biomarkers of islet beta cell stress and death in type 1 diabetes. Diabetologia 61:2259-2265, 2018

  10. Gonzalez-Duque S, Azoury ME, Colli ML, Afonso G, Turatsinze JV, Nigi L, Lalanne AI, Sebastiani G, Carré A, Pinto S, Culina S, Corcos N, Bugliani M, Marchetti P, Armanet M, Diedisheim M, Kyewski B, Steinmetz LM, Buus S, You S, Dubois-Laforgue D, Larger E, Beressi JP, Bruno G, Dotta F, Scharfmann R, Eizirik DL, Verdier Y, Vinh J, Mallone R. Conventional and Neo-Antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors. Cell Metabolism S1550-4131:30450-30459, 2018

  11. Ifie E, Russell MA, Dhayal S, Leete P, Sebastiani G, Nigi L, Dotta F, Marjomäki V, Eizirik DL, Morgan NG, Richardson SJ. Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells. Diabetologia 61:2344-2355, 2018

  12. Lytrivi M, Igoillo-Esteve M, Cnop M. Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes? Curr Opin Pharmacol 43:40-45, 2018

  13. Miani M, Elvira B, Gurzov EN. Sweet Killing in Obesity and Diabetes: The Metabolic Role of the BH3-only Protein BIM. J Mol Biol 430:3041-3050, 2018

  14. Papin J, Zummo FP, Pachera N, Guay C, Regazzi R, Cardozo AK, Herchuelz A. Na+/Ca2+ Exchanger a Druggable Target to Promote β-Cell Proliferation and Function. J Endocr Soc 2:631-645, 2018 

  15. Meyerovich K, Ortis F, Cardozo AK. The non-canonical NF-κB pathway and its contribution to β-cell failure in diabetes. J Mol Endocrinol 61:F1-F6, 2018

  16. Chase JG, Desaive T, Bohe J, Cnop M, De Block C, Gunst J, Hovorka R, Kalfon P, Krinsley J, Renard E, Preiser JC. Improving glycemic control in critically ill patients: personalized care to mimic the endocrine pancreas. Crit Care 22:182, 2018

  17. Montagne L, Derhourhi M, Piton A, Toussaint B, Durand E, Vaillant E, Thuillier D, Gaget S, De Graeve F, Rabearivelo I, Lansiaux A, Lenne B, Sukno S, Desailloud R, Cnop M, Nicolescu R, Cohen L, Zagury JF, Amouyal M, Weill J, Muller J, Sand O, Delobel B, Froguel P, Bonnefond A. CoDE-seq, an augmented whole-exome sequencing, enables the accurate detection of CNVs and mutations in Mendelian obesity and intellectual disability. Mol Metab 13:1-9, 2018

  18. Zhong L, Tran T, Baguley TD, Lee SJ, Henke A, To A, Li S, Yu S, Grieco FA, Roland J, Schultz PG, Eizirik DL, Rogers N, Chartterjee AK, Tremblay MS, Shen W. A novel inhibitor of inducible NOS dimerization protects against cytokine-induced rat beta cell dysfunction. Br J Pharmacol 175:3470-3485, 2018

  19. Nardelli TR, Vanzela EC, Benedicto KC, Brozzi F, Fujita A, Cardozo AK, Eizirik DL, Boschero AC, Ortis F. Prolactin protects against cytokine-induced beta-cell death by NFκB and JNK inhibition. J Mol Endocrinol 61:25-36, 2018

  20. Mastracci TL, Turatsinze JV, Book BK, Restrepo IA, Pugia MJ, Wiebke EA, Pescovitz MD, Eizirik DL, Mirmira RG. Distinct gene expression pathways in islets from individuals with short- and long-duration type 1 diabetes. Diabetes Obes Metab 20:1859-1867, 2018

  21. Bugliani M, Syed F, Paula FMM, Omar BA, Suleiman M, Mossuto S, Grano F, Cardarelli F, Boggi U, Filipponi F, Marselli L, De Tata V, Ahren B, Eizirik DL. Marchetti P DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes. Mol Cell Endocrinol 473:186-193, 2018

  22. Eizirik DL, Op de Beeck A. Coxsackievirus and type 1 diabetes – the wolf’s footprints. Trends Endocrinol Metab 29(3):137-139, 2018

  23. He X, Lai Q, Cai C, Li N, Sun F, Huang W, Zhang S, Yu Q, Yang P, Xiong F, Chen Z, Gong Q, Ren B, Weng J, Eizirik DL, Zhou Z, Wang C-Y. Both conditional ablation and overexpression of E2 SUMO-conjugating enzyme (UBC9) in mouse pancreatic beta cells result in impaired beta cell function. Diabetologia 61:881-895, 2018

  24. Juan-Mateu J, Alvelos MI, Turatsinze JV, Villate O, Lizarraga-Mollinedo E, Grieco FA, Marroquí L, Bugliani M, Marchetti P, Eizirik DL. A SRp55-regulated alternative splicing network controls pancreatic beta cell survival and function. Diabetes 67(3):423-436, 2018

  25. Paula FMM, Leite NC, Borck PC, Freitas-Dias R, Cnop M, Chacon-Mikahil MPT, Cavaglieri CR, Marchetti P, Boschero AC, Zoppi CC, Eizirik DLExercise training protects human and rodent βcells against endoplasmic reticulum stress and apoptosis. FASEB J 32(3):1524-1536, 2018

  26. Coomans de Brachene A, Dos Santos R, Marroqui L, Colli ML, Marselli L, Mirmira RG, Marchetti P, Eizirik DL IFN-alpha induces a preferential long-lasting expression of MHC cells I in human pancreatic beta cells. Diabetologia 61:636–640, 2018

  27. Calderari S, Ria M, Gerard C, Nogueira TC, Villate O, Collins SC, Neil H, Gervasi N, Hue C, Suarez-Zamorano N, Prado C, Cnop M, Bihoreau M-T, Kaisaki PJ, Cazier J-B, Julier C, Werner M, Eizirik DL, Gauguier D Molecular genetics of the transcription factor GLIS3 identifies its dual function in beta cells and neurons. Genomics 110:98–111, 2018

  28. Wali JA, Galic S, Tan CY, Gurzov EN, Frazier AE, Connor T, Ge J, Pappas EG, Stroud D, Varanasi LC, Selck C, Ryan MT, Thorburn DR, Kemp BE, Krishnamurthy B, Kay TW, McGee SL, Thomas HE Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice. Cell Death Diff 25:217-225, 2018



  1. Cnop M, Klupa T, Tentolouris N, Novials A, Burcelin R and Van Eimeren M. Europe has to step up its efforts to produce innovative and safe diabetes technology. Diabetologia 60:2532-2533, 2017

  2. Cnop M, Toivonen S, Igoillo-Esteve M and Salpea P. Endoplasmic reticulum stress and eIF2α phosphorylation: the Achilles heel of pancreatic β cells. Mol Metab 6:1024-1039, 2017

  3. Ciregia F, Bugliani M, Ronci M, Giusti L, Boldrini C, Mazzoni MR, Mossuto S, Grano F, Cnop M, Marselli L, Giannaccini G, Urbani A, Lucacchini A and Marchetti P. Palmitate-induced lipotoxicity alters acetylation of multiple proteins in clonal β cells and human pancreatic islets. Sci Rep 7:13445, 2017

  4. Patel KA, Kettunen J, Laakso M, Stančáková A, Laver TW, Colclough K, Johnson MB, Abramowicz M, Groop L, Miettinen PJ, Sheppard MH, Flanagan SE, Ellard S, Inagaki N, Hattersley AT, Tuomi T, Cnop M, Weedon MN. Heterozygous RFX6 protein truncating variants are associated with Maturity-Onset Diabetes of the Young (MODY) with reduced penetrance. Nat Commun 8:888, 2017

  5. Spigoni V, Fantuzzi F, Fontana A, Cito M, Derlindati E, Zavaroni I, Cnop M, Bonadonna RC and Dei Cas A Stearic acid at physiologic concentrations induces in vitro lipotoxicity in circulating angiogenic cells. Atherosclerosis 265:162-171, 2017

  6. Abdulkarim B, Hernangomez M, Igoillo-Esteve M, Cunha DA, Marselli L, Marchetti P, Ladriere L and Cnop M Guanabenz sensitizes pancreatic β cells to lipotoxic endoplasmic reticulum stress and apoptosis. Endocrinology 158:1659-1670, 2017

  7. Boscolo M, Féry F and Cnop M Beneficial outcomes of sleeve gastrectomy in a morbidly obese patient with Bardet-Biedl syndrome. J Endocr Soc 1:317-322, 2017

  8. Balhuizen A, Massa S, Mathijs I, Turatsinze J-V, De Vos J, Demine S, Xavier C, Villate O, Millard I, Egrise D, Capito C, Scharfmann R, In’t Veld P, Marchetti P, Muylderman S, Goldman S, Lahoutte T, Bouwens L, Eizirik DL, Devoogdt N. A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells. Sci Rep 7: 15130, 2017

  9. Litwak SA, Pang L, Galic S, Igoillo-Esteve M, Stanley WJ, Turatsinze J-V, Loh K, Thomas HE, Sharma A, Trepo E, Moreno C, Gough DJ, Eizirik DL, de Haan JB, Gurzov EN JNK activation of BIM promotes hepatic oxidative stress, steatosis and insulin resistance in obesity. Diabetes 66:2973 -2986, 2017

  10. Cunha DA, Cito M, Grieco FA, Cosentino C, Danilova T, Ladriere L, Lindahl M, Domansky A, Bugliani M, Marchetti P, Eizirik DL, Cnop M. Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum stress proteins thrombospondin 1 andmesencephalic astrocyte-derived neurotrophic factor (MANF). J Biol Chem 292:14977-14988, 2017

  11. Meyerovich K, Violato NM, Fukaya M, Dirix V, Pachera N, Marselli L, Marchetti P, Strasser A, Eizirik DL, Cardozo AK MCL-1 is a key anti-apoptotic protein in human and rodent pancreatic β-cells. Diabetes 66: 2446-2458, 2017

  12. Dos Santos RS, Marroqui L, Grieco FA, Marselli L, Suleiman M, Henz SR, Marchetti P, Wernersson R, Eizirik DL Protective role of complement C3 against cytokine-mediated beta-cell apoptosis. Endocrinology 158:2503-2521, 2017

  13. Bergman M-L, Lopes-Carvalho T, Martins A-C, Grieco FA, Eizirik DL, Demengeot J Tolerizing insulin therapy precipitates type 1 diabetes. J Exp Med 214:2153-2156, 2017

  14. Lee S-H, Cunha D, Piermarocchi C, Paternostro G, Pinkerton A, Ladriere L, Marchetti P, Eizirik DL, Cnop M, Levine F High-through put screening and bioinformatics analysis to ascertain compounds that prevent saturated fatty acid-induced β-cell apoptosis. Biochem Pharmacol 138:140-149, 2017

  15. Eizirik DL, Brachene AC Checks and balances – the limits of β-cell endurance to ER stress (Commentary). Diabetes 66:1467-1469, 2017

  16. Berchtold L, Miani M, Diep TA, Madsen AN, Cigliola V, Colli M, Krivokapic JM, Pociot F, Eizirik DL, Meda P, Holst B, Billestrup N, Storling J Pannexin-2 deficiency sensitizes pancreatic beta-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo. Mol Cell Endocrinol 448: 108-121, 2017

  17. Juan-Mateu J, Rech TH, Villate O, Wendt A, Turatsinze J-V, Brondani LA, Nardelli TR, Nogueira T, Esguerra JLS, Marchetti P, Eliasson L, Eizirik DL Neuron-enriched RNA-binding proteins regulate pancreatic beta cell function and survival. J Biol Chem 292:3466-3480, 2017

  18. Dos Santos RS, Daures M, Philippi A, Romero S, Marselli L, Marchetti P, Senee V, Bacq D, Besse C, Baz B, Marroqui L, Ivanoff S, Masliah-Planchon J, Nicolino M, Soulier J, Socie G, Eizirik DL, Gautier J-F*, Julier C. dUTPase (DUT) is mutated in a novel monogenic syndrome with diabetes and bone marrow failure. Diabetes 66:1086-1096, 2017

  19. Marroqui L, Santos RSD, Op de Beeck A, Brachene AC, Marselli L, Marchetti P, Eizirik DL Interferon-alpha mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes. Diabetologia 60:656-667, 2017

  20. Ben-Othman N, Vieira A, Courtney M, Record F, Gjernes E, Avolio F, Hadzic B, Druelle N, Napolitano T, Sanz SN, Silvano S, Keith A-H, Pfeifer A, Lacas-Gervais S, Leuckx G, Marroqui L, Thevenet J, Madsen O, Eizirik DL, Heimberg H, Kerr-Conte J, Pattou F, Mansouri A, Collombat P Long-term GABA administration induces alpha-cell-mediated beta-like neogenesis. Cell 168:73-85, 2017

  21. Pilkington EH, Lai M, Ge X, Stanley WJ, Wang B, Wang M, Kakinen A, Sani MA, Whittaker MR, Gurzov EN, Ding F, Quinn JF, Davis TP, Ke PC Star Polymers Reduce IAPP Toxicity via Accelerated Amyloid Aggregation. Biomacromolecules 18(12):4249-4260, 2017

  22. Loh K, Shi YC, Walters S, Bensellam M, Lee K, Dezaki K, Nakata M, Ip CK, Chan JY, Gurzov EN, Thomas HE, Waibel M, Cantley J, Kay TW, Yada T, Laybutt DR, Grey ST, Herzog H Inhibition of Y1 receptor signaling improves islet transplant outcome. Nature Commun 8(1):490, 2017

  23. Stanley WJ, Trivedi PM, Sutherland AP, Thomas HE, Gurzov EN Differential regulation of pro-inflammatory cytokine signalling by protein tyrosine phosphatases in pancreatic β-cells. J Mol Endocrinology 59:325-337, 2017

  24. Ge X, Kakinen A, Gurzov EN, Yang W, Pang L, Pilkington EH, Govindan-Nedumpully P, Chen P, Separovic F, Davis TP, Ke PC, Ding F Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation. Chemical Communications 53:9394-9397, 2017

  25. 33. Grieco FA, Sebastiani G, Mateu JM, Villate O, Marroqui L, Ladriere L, Tugay K, Regazzi R, Bugliani M, Marchetti P, Dotta F, Eizirik DL MicroRNAs miR-23a-3p, miR23-b-3p and miR-149-5p regulate the expression of pro-apoptotic BH3-only proteins DP5 and PUMA in human pancreatic islets. Diabetes 66:100-112, 2017

  26. Brondani LA, Rech TH, Boelter G, Bauer AC, Leitao CB, Eizirik DL, Crispim D UCP2 expression is increased in pancreas from brain-dead donors and involved in cytokine-induced apoptosis. Transplantation 101:e59-e67, 2017



  1. Gurzov EN, Stanley WJ, Pappas EG, Thomas HE, Gough DJ. The JAK/STAT Pathway in Obesity and Diabetes. FEBS J 283:3002-3015, 2016

  2. Jhala G, Chee J, Trivedi PM, Selck C, Gurzov EN, Graham KL, Thomas HE, Kay TW, Krishnamurthy B. Perinatal Tolerance to Proinsulin is Sufficient to Prevent Autoimmune Diabetes. JCI Insight 1:e86065, 2016

  3. Litwak SA, Stanley WJ, Pappas EG, Wali JA, Selck C, Strasser A, Thomas HE, Gurzov EN. p53-upregulated modulator of apoptosis (PUMA)-deficiency affects leptin levels but does not improve glucose homeostasis in obesity. Sci Rep 6:23802, 2016

  4. Pilkington EH, Gurzov EN, Kakinen A, Litwak SA, Stanley WJ, Davis TP, Ke PC. Pancreatic b-cell Membrane Fuidity and Toxicity Induced by Human Islet Amyloid Polypeptide Species. Sci Rep 6:21274 2016

  5. Gurzov EN, Wang B, Pilkington EH, Chen P, Kakinen A, Stanley WJ, Litwak SA, Davis TP, Ding F, Ke PC. Inhibition of hIAPP Amyloid Aggregation and Pancreatic b-cell Toxicity by OH-terminated PAMAM Dendrimer. Small 12:1615-1626, 2016

  6. Klionsky DJ et al (2000 co-authors including Cnop M). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12:1-222, 2016

  7. Himpe E, Cunha DA, Song I, Bugliani M, Marchetti P, Cnop M and Bouwens L. Phenylpropenoic acid glucoside from rooibos protects pancreatic β cells against cell death induced by acute injury. PLoS One 11:e0157604, 2016

  8. Cunha DA, Carlsson P-O, Molkentin JD, Bugliani M, Marchetti P, Eizirik DL, Cnop M. Thombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway. Cell Death Diff 23:1995-2006, 2016

  9. Quesada-Lopez T, Cereijo R, Turatsinze J-V, Planavila A, Cairo M, Gavalda-Navarro A, Peyrou M, Moure R, Iglesias R, Giralt M, Eizirik DL, Villarroya F The lipid sensor GPR120 mediates a novel pathway of brown fat activation involving FGF21. Nature Commun 7:13479, 2016

  10. Cheng J, Song J, He X, Zhang M, Hu S, Zhang S, Yu Q, Yang P, Xiong F, Wang WD, Zhou J, Ning Q, Chen Z, Eizirik DL, Zhou Z, Zhao C, Wang C-Y. Loss of Mbd2 protects mice against high-fat diet-induced obesity and insulin resistance by regulating the homeostasis of energy storage and expenditure. Diabetes 65:3384-3395, 2016

  11. Willeken SMA, Joosten L, Boerman OC, Balhuizen A, Eizirik DL, Gotthardt M, Brom M. Strain differences determine the suitability of animal models for non-invasive in vivo beta cell mass determination with radiolabeled exendin. Mol Imaging Biol 18:705-714, 2016

  12. Brozzi F, Gerlo S, Juusola M, Grieco FA, Balhuizen A, Lievens S, Gysemans C, Bugliani M, Mathieu C, Marchetti P, Tavernier J, Eizirik DL. Ubiquitin D regulates IRE1alpha/JNK-dependent apoptosis in pancreatic beta cells. J Biol Chem 291:12040-1256, 2016

  13. Op de Beeck A, Eizirik DL. Viral infections in type 1 diabetes mellitus—why the β cells?. Nature Rev Endocrinol 12:263-273, 2016

  14. Brozzi F, Eizirik DL. ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes. Upsala J Med Science 121:133-139, 2016

  15. Santin I, Santos RSD, Eizirik DL. Pancreatic beta cell survival and signaling pathways: effects of type 1 diabetes-associated genetic variants. Methods Mol Biol 1433:21-54, 2016

  16. Juan-Mateu J, Villate O, Eizirik DL. Alternative splicing: the new frontier in diabetes research. Eur J Endocrinol 174:R225-38, 2016

  17. Meyerovich K, Fukaya M, Terra LF, Ortis F, Eizirik DL, Cardozo AK. The non-canonical NF-kappaB pathway is induced by cytokines in pancreatic beta cells and contributes to cell death and proinflammatory responses in vitro. Diabetologia 59: 512-521, 2016



  1. Cnop M. Women in metabolism - Miss β cell. Cell Metab 22:952, 2015

  2. Kyrilli A, Igoillo-Esteve M, Féry F, Grieco FA, Eisendrath P, Blocklet D, Goldman S, Henquin JC, Gotthardt M and Cnop M. Insulinoma localization by glucagon-like peptide-1 receptor imaging after 18 years of hypoglycemia. AACE Clinical Case Reports 1:e187-e193, 2015

  3. Oliveira AF, Cunha DA, Ladriere L, Igoillo-Esteve M, Bugliani M, Marchetti P and Cnop M. In vitro use of free fatty acids bound to albumin: a comparison of protocols. BioTechniques 58:228-233, 2015

  4. Fjeld K, Weiss FU, Lasher D, Rosendahl J, Chen JM, Johansson BB, Kirsten H, Ruffert C, Masson E, Steine SJ, Bugert P, Cnop M, Grützmann R, Mayerle J, Mössner J, Ringdal M, Schulz HU, Sendler M, Simon P, Sztromwasser P, Torsvik J, Scholz M, Tjora E, Férec C, Witt H, Lerch MM, Njølstad PR, Johansson S and Molven A. A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis. Nat Genet 47:518-522, 2015

  5. Martino L, Masini M, Bugliani M, Marselli L, Suleiman M, Boggi U, Nogueira TC, Filipponi F, Campani D, Dotta F, Syed F, Eizirik DL, Marchetti P, De Tata V. Mast cells infiltrate pancreatic islets in human type 1 diabetes. Diabetologia 58:2554-2562, 2015

  6. Marroqui L, Santos RSD, Floyel T, Grieco FA, Santin I, Op de beeck A, Marselli L, Marchetti P, Pociot F, Eizirik DL. TYK2, a candidate gene for type 1 diabetes, modulates apoptosis and the innate immune response in pancreatic β-cells. Diabetes 64:3808-3817, 2015

  7. Delatte B, Jeschke J, Defrance M, Balhman M, Creppe C, Calonne E, Bizet M, Deplus R, Marroqui L, Libin M, Ravichandran M, Marscart F, Eizirik DL, Murrel A, Jurkowsko TP, Fuks F. Genome-wide hydroxymethylcytosine pattern changes in response to oxidative stress. Sci Rep 5:e12714, 2015

  8. Abdulkarim B, Nicolino M, Igoillo-Esteve M, Duares M, Romero S, Philippi A, Senee V, Lopes M, Cunha DA, Harding HP, Derbois C, Bendelac N, Hattersley AT, Eizirik DL, Ron D, Cnop M, Julier C. A missense mutation in PPP1R15B causes a syndrome including diabetes, short stature and microcephaly. Diabetes 64: 3951-3962, 2015

  9. Brozzi F, Nardelli TR, Lopes M, Millard I, Barthson J, Igoillo-Esteve M, Grieco FA, Villate O, Oliveira JM, Casimir M, Bugliani M, Engin F, Hotamisligil GS, Marchetti P, Eizirik DL. Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta-cells via different mechanisms. Diabetologia 58:2307-2316, 2015

  10. Marroqui L, Lopes M, Santos RSD, Roivainen M, Richardson S, Morgan N, Op de Beeck A, Eizirik DL. Differential cell autonomous immune responses determine the outcome of coxsackievirus infections in pancreatic alpha and beta cells. eLife 4:e06990, 2015

  11. Marroqui L, Masini M, Merino B, Grieco FA, Millard I, Dubois C, Quesada I, Marchetti P, Cnop M, Eizirik DL Pancreatic beta cells are resistant to metabolic stress-induced apoptosis in type 2 diabetes. EBioMedicine 2:378-385, 2015

  12. Burtea C, Laurent S, Crombez D, Delcambre S, Sermeus C, Millard I, Rorive S, Flamez D, Beckers M-C, Salmon I, Elst LV, Eizirik DL, Muller RJ. Development of a peptide-functionalized imaging nanoprobe for the targeting of FXYD2gammaa as a highly specific biomarker of pancreatic beta cells. Contrast Media Mol Imaging 10:398-412, 2015

  13. Ferreira GB, Vanherwegen A-S, Eelen G, Gutierrez ACF, Van Lommel L, Marchal K, Verlienden L, Verstuyf A, Nogueira T, Georgiadou M, Schuit F, Eizirik DL, Gysemans C, Carmeliet P, Overbergh L, Mathieu C. Vitamin D3 induces tolerance in human dendritic cells by activation of intracellular metabolic pathways. Cell Reports 10:711-725, 2015

  14. Patel D, Ythier D, Brozzi F, Eizirik DL, Thorens B. Clic4, a novel protein that sensitizes beta-cells to apoptosis. Mol Metab 4:253-64, 2015

  15. Igoillo-Esteve M, Gurgul-Convey E, Hu A, Dos Santos LRB, Abdulkarim B, Chintawar S, Marselli L, Marchetti P, Jonas J-C, Eizirik DL, Pandolfo M, Cnop M. Unveiling common mechanisms of apoptosis in β-cells and neurons in Friedreich’s ataxia. Human Mol Genet 24:2274-86, 2015

  16. Gurzov EN, Stanley WJ, Brodnicki TC, Thomas HE. Protein tyrosine phosphatases: molecular switches in metabolism and diabetes. Trends Endocrinol Metab 26:30-39, 2015

  17. Nedumpully-Govidan P, Gurzov EN, Chen P, Pilkington EH, Stanley WJ, Litwak SA, Davis TP, Ke PC, Ding F. Graphene Oxide Inhibits hIAPP Amyloid Fibrillation and Toxicity in Insulin-Producing NIT-1 Cells. Physical Chemistry Chemical Physics 18:94-100, 2015

  18. Litwak SA, Wali JA, Pappas E, Saadi H, Stanley WJ, Varanasi LC, Kay TW, Thomas HE, Gurzov EN. Lipotoxic stress induces pancreatic beta cell death through modulation of Bcl-2 proteins by the ubiquitin/proteasome system. J Diabetes Res 2015:280615, 2015

  19. Krishnamurthy B, Chee J, Jhala G, Trivedi P, Catterall T, Selck C, Gurzov EN, Brodnicki TC, Graham KL, Wali JA, Zhan Y, Gray D, Strasser A, Allison J, Thomas HE, Kay TW. Bim deficiency protects NOD mice from diabetes by diverting thymocytes to regulatory T cells. Diabetes 64:3229-3238, 2015

  20. Stanley WJ, Litwak SA, Quah HS, Tan SM, Kay TW, Tiganis T, de Haan JB, Thomas HE, Gurzov EN. Inactivation of protein tyrosine phosphatases enhances interferon signaling in pancreatic islets. Diabetes 64:2489-2496, 2015

  21. Rondas D, Crevecouer I, D’Hertog W, Ferreira GB, Staes A, Garg AD, Eizirik DL, Agostinis P, Gevaert K, Overbergh L, Mathieu C. Citrullinated glucose-regulated protein 78 is an autoantigen in type 1 diabetes. Diabetes 64:573-86, 2015



  1. Corben LA, Lynch D, Pandolfo M, Schulz JB, Delatycki MB, and the Clinical Management Guidelines Writing Group Balcer L, Bartek R, Bates C, Campagna E, Cnop M, Dürr A, Emmanuel A, Farmer J, Flynn J, Friedman LS, Giunti P, Hadjivassiliou M, Ho M, Isaya G, Kearney M, Loucas M, Marotti C, Milne S, Morlet T, McGarry A, Panicker J, Parkinson M, Payne RM, Peverill R, Rance G, Rodriguez L, Schadt KA, Seyer L, Subramony SH, Sullivan KL, Vogel A, Yiu E, Yoon G, Zesiewicz TA. Clinical management guidelines for Friedreich ataxia. Orphanet J Rare Dis 9:184, 2014

  2. Mathijs I, Cunha DA, Himpe E, Ladriere L, Chellan N, Roux RC, Joubert E, Muller C, Cnop M, Louw J and Bouwens L. A phenylpropenoic acid glucoside phytochemical augments pancreatic β cell mass in high-fat diet-fed mice and protects β cells from ER stress-induced apoptosis. Mol Nutr Food Res 58:1980-1990, 2014

  3. Villate O, Turatsinze J-V, Mascali LG, Grieco FA, Nogueira TC, Cunha DA, Nardelli TR, Sammeth M, Salunkhe VA, Esguerra JLS, Eliasson L, Marselli L, Marchetti P, Eizirik DL. Nova1 is a master regulator of alternative splicing in pancreatic beta cells. Nucleic Acid Res 42:11818-11830, 2014

  4. Brozzi F, Gerlo S, Grieco FA, Nardelli TR, Lievens S, Gysemans C, Marselli L, Marchetti P, Mathieu M, Tavernier J, Eizirik DL. A combined “omics” approach identifies NMI as a novel cytokine-induced regulator of IRE1α and JNK in pancreatic beta cells. J Biol Chem 289:20677-20693, 2014

  5. Eizirik DL, Millard I. Stress du reticulum endoplasmique et apoptose de la cellule beta dans le diabete. Chronique d’une mort annoncee (French). Medecine/Sciences 30:496-499, 2014

  6. Fløyel T, Brorsson C, Nielsen LB, Miani M, Bang-Berthelsena CH, Friedrichsend M, Overgaarda AJ, Berchtolda LA, Wiberge A, Poulsenf P, Hansena L, Rosingerg S, Boehmg B, Rami R, Nguyeni Q, Mehtai M, Morahani G, Concannon P, Bergholdt R, Nielsen JH, Reinheckelm T, von Herrathe M, Vaag A, Eizirik DL, Mortensen HB, Størling J, Pociot F. CTSH regulates β-cell function and disease progression in newly-diagnosed type 1 diabetes patients. Proc Natl Acad Sci USA 111: 10305-10310, 2014

  7. Zhong J, Yu Q, Yang P, He L, Fang J, Tu Y, Zhang Z, Lai Q, Zhang S, Rao X, Kucsma M, Kraj P, Xu J-F, Gong F, Zhou J, Wen L, Eizirik DL, Du J, Wang W, Wang C-Y. MBD2 regulates TH17 differentiation by controlling the homeostasis of T-bet/Hlx axis through binding to methylated CpG DNA. J Autoimmun 53:95-104, 2014

  8. Cunha DA, Gurzov EN, Naamane N, Ortis F, Cardozo AK, Bugliani M, Marchetti P, Eizirik DL, Cnop M. JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway. Cell Death Diff 21:1313-1324, 2014

  9. Marroqui L, Santin I, Santos RS, Marselli L, Marchetti P, Eizirik DL. BACH2, a candidate risk gene for type 1 diabetes, regulates apoptosis in pancreatic β-cells via JNK1 modulation and cross talk with the candidate gene PTPN2. Diabetes 63: 2516-2527, 2014

  10. Gotthardt M, Eizirik DL, Cnop M, Brom M. In vivo imaging of pancreatic beta cells – a key tool for developing optimized diabetes prevention and treatment. Trends Endocrinol Metab25:375-377, 2014

  11. Hakonen E, Ustinov J, Eizirik DL, Sariola H, Miettinen PJ, Otonkoski T. In vivo activation of the PI3K/Akt pathway in mouse beta cells by the EGFR mutation L858R protects against diabetes.Diabetologia 57:970-979, 2014

  12. Brom M, Joosten L, Frielink C, Verwijnen S, Bouckenooghe T, Rijken P, Andralojc K, Göke BJ, de Jong M, Eizirik DL, Béhé M, Oyen W, Boerman O, Gotthardt M. Non-invasive determination of the beta-cell mass by SPECT imaging with 111In-DTPA-Exendin-3 in a rat model of type 1 diabetes. Diabetologia 57:950-959, 2014

  13. Lopes M, Kutlu B, Miani M, Bang-Berthelsen C, Størling J, Pociot F; Goodman N, Hood L, Welsh N, Bontempi G, Eizirik DL. Temporal profiling of cytokine-induced genes in pancreatic beta-cells by meta-analysis and network inference. Genomics 103: 264-75, 2014

  14. Cnop M, Abdulkarim B, Bottu G, Cunha DA, Igoillo-Esteve Mariana, Masini M, Turatsinze J-V, Griebel T, Villate O, Santin I, Bugliani M, Ladriere L, Marselli L, McCarthy MI, Marchetti M, Sammeth M, Eizirik DL. RNA-sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate. Diabetes 63:1978–1993, 2014

  15. Wolden-Kirk H, Rondas D, Bugliani M, Korf H, Van Lommel L, Brusgaard K, Christensen HT, Schuit F, Proost P, Masini M, Marchetti P, Eizirik DL, Overbergh L, Mathieu C. Discovery of molecular pathways mediating 1,25-dihydroxyvitamin D3 protection against cytokine-induced inflammation and damage of human and male mouse islets of Langerhans. Endocrinology 155:736-747, 2014

  16. Wali JA, Gurzov EN, Fynch S, Elkerbout L, Kay TW, Masters SL, Thomas HE. Activation of the inflammasome complex is not required for stress-induced death of pancreatic islets. PLoS One 9: e113128, 2014

  17. Gurzov EN, Tran M, Fernandez-Rojo M, Merry T, Zhang X, Xu Y, Fukushima A, Waters MJ, Watt M, Andrikopoulos S, Neel BG, Tiganis T. Hepatic oxidative stress promotes insulin-STAT5 signaling and obesity by inactivating PTPN2. Cell Metab 20:85-102, 2014

  18. Wali JA, Rondas D, McKenzie MD, Zhao Y, Elkerbout L, Fynch S, Gurzov EN, Akira S, Mathieu C, Kay TW, Overbergh L, Strasser A, Thomas HE. The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity. Cell Death Dis 5: e1124, 2014

  19. Grieco FA, Moore F, Vigneron F, Santin I, Villate O, Marselli L, Rondas D, Korf H, Overbergh L, Dotta F, Marchetti P, Mathieu C, Eizirik DL. IL-17A increases the expression of pro-inflammatory chemokines in human pancreatic islets. Diabetologia 57:502-511, 2014



  1. Arsenijevic T, Vujovic A, Libert F, Op de Beeck A, Hébrant A, Janssens S, Grégoire F, Lefort A, Bolaky N, Perret J, Caspers L, Willermain F, Delporte C. Hyperosmotic stress induces cell cycle arrest in retinal pigmented epithelial cells. Cell Death Dis 4:e662, 2013

  2. Poncelet L, Héraud C, Springinsfeld M, Ando K, Kabova A, Beineke A, Peeters D, Op De Beeck A, Brion JP. Identification of feline panleukopenia virus proteins expressed in Purkinje cell nuclei of cats with cerebellar hypoplasia. Vet J 196:381-7, 2013

  3. Cnop M, Mulder H and Igoillo-Esteve M. Diabetes in Friedreich ataxia. J Neurochem 126 Suppl 1:94-102, 2013

  4. Maris M, Robert S, Waelkens E, Derua R, Hernangomez M, d’Hertog W, Cnop M, Mathieu C and Overbergh L. The role of the saturated non-esterified fatty acid palmitate in beta cell dysfunction. J Proteome Res 12:347-362, 2013

  5. Feyza E, Yermalovich A, Ngyuen T, Hummasti S, Fu W, Eizirik DL, Mathis D, Hotamisligil GS. Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes. Science Transl Med 5:211ra156, 2013

  6. Igoillo-Esteve M, Genin A, Lambert N, Désir J, Pirson I, Abdulkarim B, Simonis N, Drielsma A, Marselli L, Marchetti P, Vanderhaeghen P, Eizirik DL, Wuyts W, Julier C, Chakera AJ, Ellard S, Hattersley AT, Abramowicz M, Cnop M. tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans. PLoS Genet 9:e1003888, 2013

  7. Santin I, Eizirik DL. Candidate genes for type 1 diabetes modulate pancreatic islet inflammation and beta-cell apoptosis. Diabetes Obes Metab 15 (Suppl. 3): 71-81, 2013

  8. Miani M, Barthson J, Coli ML, Brozzi F, Cnop M, Eizirik DL. Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1beta-induced apoptosis via Bim/A1 imbalance. Cell Death Dis 4:e701, 2013

  9. Velloso LA, Eizirik DL, Cnop M. Type 2 diabetes mellitus – an autoimune disease? Nature Rev Endocrinol 9:750–755, 2013

  10. Nogueira TC, Paula FV, Villate O, Colli ML, Moura RF, Cunha DA, Marselli L, Marchetti P, Cnop M, Julier C, Eizirik DL. GLIS3, a susceptibility gene for type 1 and 2 diabetes mellitus, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim. PLoS Genet 9:e1003532, 2013

  11. Eizirik DL, Miani M, Cardozo AK. Signalling danger – endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation. Diabetologia 56:234-241, 2013

  12. Shields BJ, Wiede F, Gurzov EN, Wee K, Hauser C, Zhu HJ, Molloy TJ, O’Toole SA, Daly R, Sutherland RL, Mitchell CA, MacLean CA, Tiganis T. TCPTP regulates Src and STAT3 signalling and is lost in triple negative breast cancer. Mol Cell Biol 33:557-570, 2013

  13. Wolden-Kirk H, Overbergh L, Gysemans C, Brusgaard K, Naamane N, Van Lommel L, Schuit F, Eizirik DL, Christesen H, Mathieu C. Unraveling the effects of 1,25(OH)2D3 on global gene expression in pancreatic islets. J Steroid Biochem Mol Biol 136:68-79, 2013



  1. Descamps V, Op de Beeck A, Plassart C, Brochot E, François C, Helle F, Adler M, Bourgeois N, Degré D, Duverlie G, Castelain S. Strong correlation between liver and serum levels of hepatitis C virus core antigen and RNA in chronically infected patients. J Clin Microbiol 50:465-8, 2012

  2. Albecka A, Belouzard S, Op de Beeck A, Descamps V, Goueslain L, Bertrand-Michel J, Tercé F, Duverlie G, Rouillé Y, Dubuisson J. Role of low-density lipoprotein receptor in the hepatitis C virus life cycle. Hepatology 55:998-1007, 2012

  3. Santin I, Moore F, Grieco FA, Marchetti P, Brancolini C, Eizirik DL. USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis. Cell Death Dis, 3:e419, 2012

  4. Eizirik DL, Cnop M. Mining genes in type 2 diabetic islets and finding gold . Cell Metab 16:555-557, 2012

  5. Peakman M, Eizirik DL, Eisenbarth GS and Pociot F. Type 1 diabetes. Nature Rev Endocrinol, epub 21:09, 2012

  6. Korf H, Mathlias W, Benoit S, Tatiana T, Sofie R, Michela M, Eizirik DL, Gysemans C, Mathieu C. 1,25dihydroxyvitamin D3 curtails the inflammatory and T cell stimulatory capacity of macrophages through an IL-10-dependent mechanism. Immunobiology 217:1292-300, 2012

  7. Cnop M. High fat feeding exacerbates endoplasmic reticulum stress and beta cell demise. Eur J Lipid Sci Technol 114:229-232, 2012

  8. Cnop M, Foufelle F and Velloso LA. Endoplasmic reticulum stress, obesity and diabetes. Trends Mol Med 18:59-68, 2012

  9. Depreter F, Burniat A, Blocklet D, Lacroix S, Cnop M, Féry F, Van Aelst N, Pilcer G, Deleers M, Goldman S and Amighi K. Comparative pharmacoscintigraphic and pharmacokinetic evaluation of two new formulations of inhaled insulin in type 1 diabetic patients. Eur J Pharm Biopharm 80:4-13, 2012

  10. Cnop M, Igoillo-Esteve M, Rai M, Begu A, Serroukh Y, Depondt C, Musuaya AE, Marhfour I, Ladriere L, Moles Lopez X, Lefkaditis D, Moore F, Brion J-P, Cooper JM, Schapira AHV, Clark A, Koeppen AH, Marchetti P, Pandolfo M, Eizirik DL, Fery F. The central role and mechanisms of beta cell dysfunction and death in Friedreich’s ataxia-associated diabetes. Ann Neurol 72:971–982, 2012

  11. Cunha DA, Igoillo-Esteve M, Gurzov EN, Germano CM, Naamane N, Marhfour I, Fukaya M, Vanderwinden JM, Gysemans C, Mathieu C, Marselli L, Marchetti P, Harding HP, Ron D, Eizirik DL, Cnop M. DP5 and PUMA mediate the ER stress-mitochondrial dialog triggering lipotoxic beta-cell apoptosis. Diabetes 61:2763-75, 2012

  12. Marhfour I, Lopez XM, Lefkaditis D, Salmon I, Allagnat F, Richardson SJ, Morgan NG, Eizirik DL. Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes. Diabetologia 55:2417–2420, 2012

  13. Allagnat F, Fukaya M, Nogueira TC, Delaroche D, Welsh N, Marselli L, Marchetti P, Haefliger JA, Eizirik DL, A.K. Cardozo. C/EBP Homologous Protein (CHOP) Contributes to cytokine-induced pro-inflammatory responses and apoptosis in beta cells. Cell Death Diff 19:1836-1846, 2012

  14. Eizirik DL, Grieco FA. On the immense variety and complexity of circumstances conditioning pancreatic beta cell apoptosis in type 1 diabetes. Diabetes 61:1661-1663, 2012

  15. Miani M, Colli M, Ladriere L, Cnop M, Eizirik DL. Mild endoplasmic reticulum stress augments the pro-inflammatory effect of IL-1beta in pancreatic rat beta cells via the IRE1alpha/XBP1s pathway. Endocrinology 153:3017-3028, 2012

  16. Andralojc K, Srinivas M, Brom M, Joosten L, de Vries IJM, Eizirik DL, Boerman OC, Meda P, Gotthardt M. Roadblocks on the way to clinical visualization of beta cells: looking for the Aeneas of molecular imaging. Diabetologia 55:1247-1257, 2012

  17. Ortis F, Miani M, Colli ML, Cunha DA, Gurzov EN, Allagnat F, Chariot A, Eizirik DL. Differential usage of NF-kB activating signals by IL-1band TNF-ain pancreatic beta cells. FEBS Lett 586:984-989, 2012

  18. Eizirik DL, Sammeth M, Bouckenooghe T, Bottu G, Sisino G, Igoillo-Esteve M, Ortis F, Santin I, Colli ML, Barthson J, Bouwens L, Hughes L, Gregory L, Lunter G, Marselli L, Marchetti P, McCarthy MI, Cnop M. The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines. PLoS Genetics 8:e1002552, 2012

  19. Moore F, Santin I, Nogueira TC, Gurzov EN, Marselli L, Marchetti P, Eizirik DL. The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells. PLoS One 7:e31062, 2012

  20. Volkmar M, Dedeurwaerder S, Cunha DA, Ndlovu MN, Defrance M, Deplus R, Calonne E, Volkmar U, Igoillo-Esteve M, Naamane N, Guerra SD, Masini M, Bugliani M, Marchetti P, Cnop M, Eizirik DL, Fuks F. DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients. EMBO J 31:1405-1426, 2012

  21. Maris M, Overbergh L, Gysemans C, Waget A, Cardozo AK, Verdrengh E, Cunha JP, Gotoh T, Cnop M, Eizirik DL, Burcelin R, Mathieu C. Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance. Diabetologia 55:1167–1178, 2012

  22. Moore F, Cunha DA, Mulder H, Eizirik DL. Use of RNA interference to investigate cytokine signal transduction in pancreatic beta cells. Methods Mol Biol 820:179-194, 2012

  23. Kolb H, Eizirik DL. Resistance to type 2 diabetes: a mater of hormesis? Nat Rev Endocrinol 8:183–192, 2012

  24. Gurzov EN, Barthson J, Mahrfour I, Ortis F, Naamane N, Igoillo-Esteve M, Gysemans C, Mathieu C, Kitajima S, Marchetti P, Ortonft TF, Bakiri L, Wagner EF, Eizirik DL. Pancreatic beta cells activate a JunB-ATF3-dependent survival pathway during inflammation. Oncogene 31:1723-1732, 2012