Postdoctoral position available!
The Cnop team studies pancreatic bcell failure in type 2 diabetes and in monogenic forms of diabetes related to endoplasmic reticulum (ER) stress, mitochondrial dysfunction and tRNA biology. To gain further insight in the pathways of bcell failure in diabetes and to test novel therapies, we have established an induced pluripotent stem cell (iPSC) facility: the differentiation of patient-derived iPSCs into human bcells provides a highly relevant disease-in-a-dish model.
The post-doctoral application is invited in the context of a project funded by the Erasmus Fund, entitled “Novel disease-in-a-dish models of rare childhood orphan diseases caused by endoplasmic reticulum stress”. Dysregulation of ER stress signaling causes bcell failure in monogenic forms of diabetes. These monogenic forms of diabetes are used as experiments of nature that provide us with human knockout models for key aspects of bcell biology. Genome editing and patient iPSCs differentiated into bcells will be used to gain mechanistic insight, using RNA-sequencing, ribosome footprint profiling and proteomic approaches. Our main goal is to identify master regulators of bcell ER stress and protein translation. The iPSC-derived bcells will also be used to test novel therapeutic targets.
The candidate will hold a PhD degree and have a strong interest in diabetes research, with the ability to work autonomously and as part of the iPSC team in our lab. Experience in stem cell biology, pancreatic bcells and molecular biology will be a major advantage.
The position is currently open and can be filled immediately. Applications are accepted until the position is filled. Please email a letter of interest, curriculum vitae (including publication list), and the name of 2-3 reference persons (with email address and telephone number) to:
Miriam Cnop, MD PhD
ULB Center for Diabetes Research, Universite Libre de Bruxelles, Brussels, Belgium
Abdulkarim B, Nicolino M, Igoillo-Esteve M, Daures M, Romero S, Philippi A, Senée V, Lopes M, Cunha DA, Harding HP, Derbois C, Bendelac N, Hattersley AT, Eizirik DL, Ron D, Cnop M and Julier C. A missense mutation in PPP1R15Bcauses a syndrome including diabetes, short stature and microcephaly. Diabetes 2015, 64:3951-3962.
Cnop M, Toivonen S, Igoillo-Esteve M and Salpea P. Endoplasmic reticulum stress and eIF2aphosphorylation: the Achilles heel of pancreatic bcells. Mol Metab 2017, 6:1024-1039.
Cosentino C, Toivonen S, Diaz Villamil E, Atta M, Ravanat JL, Demine S, Schiavo A, Pachera N, Deglasse JP, Jonas JC, Balboa D, Otonkoski T, Pearson ER, Marchetti P, Eizirik DL, Cnop M and Igoillo-Esteve M. Pancreaticbcell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes. Nucleic Acids Res 2018, 46:10302-10318.